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在液相色谱中用合成的手性固定相直接拆分外消旋化合物的方法,由于其在理论和应用上的重要意义,自70年代以来引起了众多化学家的重视,研究工作十分活跃。实验证实,聚甲基丙烯酸环氧丙酯(PGMA)树脂经功能基化反应键接手性氨基酸后,作配体交换色谱固定相可显示较好的立体识别能力。但这种树脂载体机械强度较差,同时具有树脂类手性固定相的共同弱点——聚合物中的传质过程缓慢而使柱效下降。如何克服这些缺点,是拆分研究
Due to its importance in theory and application, the direct resolution of racemic compounds from synthetic chiral stationary phases in liquid chromatography has attracted the attention of many chemists since the 1970s and the research work has been very active. Experiments show that poly (glycidyl methacrylate) (PGMA) resin has good stereo recognition ability by ligand exchange chromatographic stationary phase after chiral amino acid bonding by functionalization reaction. However, this resin carrier has poor mechanical strength and at the same time has the common weakness of resinous chiral stationary phases - the slow mass transfer in the polymer leads to a decrease in column efficiency. How to overcome these shortcomings is the split research