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目的:梳理涌吐类中药饮片的安全事件报道,分析其引发不良反应/事件(ADR/ADE)的特点及原因,提出涌吐类中药饮片的合理用药与药物警戒建议。方法:系统检索30余年来国内外文献报道,收集和整理4味涌吐类中药饮片的安全事件报道,采用回顾性研究和统计学方法分析该类中药饮片的不良反应特点及原因。结果:共收集到4味涌吐类中药饮片安全问题的文献报道23篇,案例35篇。其ADR/ADE的临床表现主要为A型不良反应,以毒副反应较为常见;主要影响因素为超剂量用药、误用滥用等。结论:涌吐类中药饮片均具有毒性,容易发生ADR/ADE且后果严重,临床上应对其可能发生安全问题的因素加以警戒,从而提高临床安全合理用药水平。
OBJECTIVE: To sort out the safety incidents reports of YM prescriptions and analyze the characteristics and causes of ADR / ADE, and to put forward the reasonable medication and warning suggestions of YM medicines. Methods: We searched the domestic and foreign literature for more than 30 years to collect and collate the safety incidents reports of 4 Chinese herbal medicine slices of Wuxong spit. We retrospectively studied and analyzed the characteristics and causes of adverse reactions of these Chinese herbal pieces. Results: A total of 23 articles were collected and 35 cases were reported in the literature on the safety of Chinese herbal medicine slices of 4 flavors and spices. The clinical manifestations of ADR / ADE mainly A-type adverse reactions to toxic side effects are more common; the main influencing factors are overdosing, misuse and abuse. Conclusion: All kinds of Chinese herbal medicine tablets are toxic and prone to ADR / ADE with serious consequences. Therefore, we should guard against the factors that may cause safety problems and improve the clinical safety and reasonable dosage.