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目的：探索血清胃蛋白酶原及胃泌素与萎缩性胃炎及胃癌的关系。方法：对已行常规胃镜检查及病理活检的154例患者(其中非萎缩性胃炎者59例,萎缩性胃炎患者52例,胃癌患者43例)检测血清胃蛋白酶原Ⅰ、Ⅱ及血清胃泌素。结果：萎缩性胃炎组及胃癌组血清胃蛋白酶原Ⅰ、血清胃蛋白酶原Ⅰ与Ⅱ比值及血清胃泌素同非萎缩性胃炎组相比有极显著差异(P＜0．01)；胃体胃窦萎缩组血清胃蛋白酶原Ⅰ、血清胃蛋白酶原Ⅰ与Ⅱ比值同胃体萎缩组或胃窦萎缩组有显著差异(P＜0．05)；但血清胃蛋白酶原Ⅰ及血清胃蛋白酶原Ⅰ与Ⅱ的比值在萎缩性胃炎组与胃癌组之间无显著差异(P＞0．05)。而胃窭萎缩组及胃体胃窦萎缩组与胃体萎缩组的血清胃泌素水平均有显著差异(P＜0．05),胃窦萎缩组与胃体胃窦萎缩组的血清胃泌素水平无显著差异(P=0．680)。结论：血清胃蛋白酶原Ⅰ、血清胃蛋白酶原Ⅰ与Ⅱ的比值及血清胃泌素的检测可以作为血清学筛查癌前病变及胃癌的有效的非侵入性的方法。
Objective: To explore the relationship between serum pepsinogen and gastrin and atrophic gastritis and gastric cancer. Methods: A total of 154 patients with conventional gastroscopy and biopsy (including 59 cases of non-atrophic gastritis, 52 cases of atrophic gastritis and 43 cases of gastric cancer) were tested for serum pepsinogen Ⅰ, Ⅱ and serum gastrin . Results: Serum pepsinogen Ⅰ, serum pepsinogen Ⅰ and Ⅱ ratio and serum gastrin in non-atrophic gastritis group were significantly different between atrophic gastritis group and gastric cancer group (P <0.01) Serum pepsinogen Ⅰ, serum pepsinogen Ⅰ and Ⅱ ratios in gastric antral atrophy group were significantly different from those in gastric atrophy group or antral atrophy group (P <0.05); however, serum pepsinogen Ⅰ and serum pepsinogen The ratio of Ⅰ and Ⅱ showed no significant difference between atrophic gastritis group and gastric cancer group (P> 0.05). The levels of serum gastrin in gastric atrophy group and gastric antral atrophy group were significantly different from those in gastric atrophy group (P <0.05) There was no significant difference between the two groups (P = 0.680). Conclusion: Serum pepsinogen Ⅰ, serum pepsinogen Ⅰ and Ⅱ ratio and serum gastrin detection can be used as a serological screening of precancerous lesions and gastric cancer effective non-invasive method.