本文报道了非均相固载型杂多酸盐催化剂ＴｉＳｉＷ１２Ｏ４０／ＴｉＯ２的制备方法，并用ＩＲ、ＸＲＤ谱对该催化剂进行了表征，研究了该催化剂的催化活性．实验表明，在以苯为带水剂时，催化剂的用量为反应液的０．５％，醇酸摩尔比为１．２０∶１，酯化反应时间为２ｈ，乙酸正丁酯的收率达７６．８％，超过硫酸、磷钨酸催化水平． In this paper, a preparation method of heterogeneous solid-supported heteropoly acid salt catalyst TiSiW12O40 / TiO2 was reported. The catalyst was characterized by IR and XRD, and the catalytic activity of the catalyst was also studied. The experimental results show that the amount of catalyst is 0.5% of the reaction liquid, the molar ratio of alcohol to acid is 1.20:1, the reaction time of esterification is 2h, the yield of n-butyl acetate is up to 76.8% over the catalytic level of sulfuric acid, phosphotungstic acid.