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自从Kimmel等(1968)在鸡胰腺中分离出鸡胰多肽(PP)以来,人们相继由哺乳动物的胰腺中分离出牛、猪、羊、狗和人的胰多肽,并确定PP是由36个氨基酸残基组成的多肽。其后(1980),在Mutt实验室又由猪十二指肠提取物中分离出一种与PP结构类似的36肽,命名为酪酪肽(PYY),所谓PP家族便开始形成。由于用鸡PP或牛PP抗血清进行免疫组织化学研究发现,PP样免疫活性物质广泛分布在中枢神经系统中,因而人们一向认为,哺乳类动物的脑中存在着一种与PP在化学结构上有一定联系的肽类物质。但用放射免疫测定法却未能测出鸡PP、牛PP免疫活性。因此,脑中PP样免疫活性的实质一直没有搞清楚。最近,Totemoto等又从猪脑中分离出一种新的神经肽,命名为神经肽Y(neuropeptide Y,NPY),
Since the isolation of chicken pancreatic polypeptide (PP) from chicken pancreas by Kimmel et al. (1968), cattle, pigs, sheep, dogs, and human pancreatic polypeptide were successively isolated from the mammalian pancreas and identified as having 36 Amino acid residues. Later on, in 1980, another 36-peptide peptide similar in structure to PP was isolated from the porcine duodenum extract in Mutt Laboratories and named as PYY. The so-called PP family began to form. Since immunohistochemistry with chicken PP or bovine PP antiserum has found that PP-like immunocompetent substances are widely distributed in the central nervous system, it has been thought that there is a chemical structure in the brain of mammals There are certain linked peptides. However, radioimmunoassay failed to measure the chicken PP, bovine PP immune activity. Therefore, the nature of PP-like immunological activity in the brain has not been clarified. Recently, Totemoto et al. Isolated a new neuropeptide from porcine brain named neuropeptide Y (NPY)