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目的:从能量代谢角度探讨《伤寒论》桂枝、甘草“辛甘化阳”的配伍内涵。方法:采用盐酸普罗帕酮诱导大鼠“心阳虚证”模型。动物末次给药后50 min,自腹主动脉采血6~8 mL,分离血清检测TC、TG、GLU、INS、GC、T3含量。结果:桂枝、甘草各配伍组均能降低TG、INS水平,增高GLU、GC含量。其中,对TG的影响以4、5、6、8组配伍较显著(P<0.05);对GLU的影响以2、4、6组配伍的增高幅度较显著(P<0.05或P<0.01);对INS的影响则以4、8组配伍的下降趋势尤为突出(P<0.05);对GC的影响则以4组配伍上升趋势较为明显(P<0.05)。结论:《伤寒论》桂枝、甘草“辛甘化阳”配伍原理的内涵与干预大鼠血清TG、GLU、INS、GC等指标的代谢有关,其作用的发挥与桂枝、甘草配伍比例及煎煮时间密切相关,桂枝、甘草用量应大于6g,煎煮时间以15~35min为宜。
Objective: To discuss the connotation of compatibility between “Gui Zhi”, “Licheng” and “Xin Gan Hua Yang” in terms of energy metabolism. Methods: Rats induced by propafenone were induced by “Heart Yang deficiency syndrome” model. 50 min after the last administration of the animals, 6-8 mL blood was taken from the abdominal aorta, and the contents of TC, TG, GLU, INS, GC and T3 were detected by serum. Results: Both Guizhi and Licorice groups could reduce TG and INS levels and increase GLU and GC contents. Among them, the effects of TG on group 4, 5, 6 and 8 were significant (P <0.05); the influence on GLU was more significant (P <0.05 or P <0.01) (P <0.05). The effects of GC on the GC were more obvious in the four groups (P <0.05). CONCLUSION: The connotation of compatibility principle of “Shanggan Lun” Gui Zhi and “Xin Gan Hua Yang” is related to the metabolism of serum TG, GLU, INS, GC and other indicators in rats, and its function is compatible with Guizhi and Liquorice The proportion and boiling time are closely related, Gui, licorice dosage should be greater than 6g, boiling time to 15 ~ 35min appropriate.