Objective To elucidate the effect of Ge 132 on the growth of melanocytes.Methods Melanocyes from epidermis were cultured and purified;the second generation of the cell was used for study;the cells were divided into two groups randomly,to group A, Ge 132 was added to the media at 0.04mg/L;to group B,common culturing method was used without Ge 132.After 5d, the cells were seperated by digestion for study by transmission electronic microscope.Results Compared to group B, the vaculoes of the cells were increased,mitochondria distended, endoplasmic reticulum dilated and the number of melanosome declined in the group A.Conclusion Ge 132 can inhibit the melanocytes growth at a certain concentration and might be used for treating pigmented diseases. Objective To elucidate the effect of Ge 132 on the growth of melanocytes. Methods Melanocyes from epidermis were cultured and purified; the second generation of the cell was used for study; the cells were divided into two groups randomly, to group A, Ge 132 was added to the media at 0.04 mg / L; to group B, common culturing method was used without Ge 132. After 5d, the cells were seperated by digestion for study by transmission electronic microscope. Results Compared to group B, the vaculoes of the cells were increased, mitochondria distended, endoplasmic reticulum dilated and the number of melanosome declined in the group A. Confluent Ge 132 can inhibit the melanocyte s growth at a certain concentration and might be used for treating pigmented diseases.