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目的:观察鼻渊息胶囊对急性鼻炎小鼠的疗效及其抗炎、镇痛作用。方法:采用二甲苯鼻腔滴入方法制备急性鼻炎小鼠模型;采用二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增高,大鼠棉球肉芽肿实验;采用小鼠醋酸扭体实验。结果:鼻渊息胶囊能够明显减少急性鼻炎小鼠鼻腔黏膜的炎细胞浸润,减少分泌物及渗出物;对二甲苯所致小鼠耳肿、醋酸致小鼠腹腔毛细血管通透性增高、大鼠棉球致肉芽组织增生均有显著的抑制作用;对醋酸引起的小鼠扭体次数有明显减少。结论:鼻渊息胶囊有明显的抗炎,镇痛作用,是治疗鼻炎的有效药物。
Objective: To observe the curative effect and the anti-inflammatory and analgesic effect of Biyuan Capsule on acute rhinitis mice. Methods: Acute rhinitis mouse model was prepared by nasal instillation of xylene. The auricle of mouse was swollen with xylene, the peritoneal capillary permeability of mice induced by acetic acid was increased. The rat granuloma granuloma was tested. Acetic acid Twisting body experiment. Results: Nao Yuan Capsule can significantly reduce inflammatory cell infiltration in nasal mucosa of acute rhinitis mice and reduce secretions and exudates; the paracentescent permeability of mice induced by xylene is increased, Rat granulation tissue caused by granulation tissue hyperplasia were significantly inhibited; acetic acid induced writhing in mice significantly reduced. Conclusion: Bi Yuan Capsule has obvious anti-inflammatory and analgesic effects and is an effective drug for the treatment of rhinitis.