含镍合金在口腔治疗中应用广泛,尤其在正畸学领域,包括金属托槽、弓丝、带环、推簧和结扎丝等,几乎伴随在正畸治疗的整个过程中。应用于人体的材料必须具有良好的生物安全性。近年来,随着人们健康意识的提高,口腔材料的腐蚀和其潜在的毒性作用已逐渐受到关注。本文将针对正畸治疗中含镍合金生物安全性的研究进展作一综述,具体包括镍离子的释放,含镍合金致敏性、细胞毒性、致癌性以及机体其他器官的不良反应等内容。 Nickel-containing alloys are widely used in oral treatment, especially in the field of orthodontics, including metal brackets, arch wires, band rings, push springs and ligature wires, which are almost accompanied by the entire process of orthodontic treatment. Materials applied to the human body must have good biosafety. In recent years, with the improvement of people’s health awareness, the corrosion of oral materials and their potential toxic effects have drawn more and more attention. This article reviews the research progress of bio-safety of nickel-containing alloys in orthodontic treatment, including release of nickel ions, sensitization of nickel-containing alloys, cytotoxicity, carcinogenicity and adverse reactions in other organs of the body.