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目的探讨组合型人工肾[血液灌流(HP)联合血液透析(HD)]在降低HD患者血清甲状旁腺素(PTH)水平中的作用。方法 34例接受维持性血液透析的尿毒症患者,按照数字表法分为研究组和对照组,每组17例。研究组采用HP+HD治疗,而对照组则采用单纯HD治疗。比较两组患者治疗前后血钙、血磷、PTH的变化情况。结果治疗前两组血钙、血磷、PTH水平比较差异均无统计学意义(P>0.05)。治疗后两组血钙水平与治疗前比较差异均无统计学意义(P>0.05),且组间比较差异无统计学意义(P>0.05);治疗后两组血磷、PTH水平与治疗前比较差异均具有统计学意义(P<0.05)。治疗后研究组血磷(1.87±0.24)mmol/L、PTH(285.01±27.88)pg/ml低于对照组(2.47±0.20)mmol/L、(310.52±24.36)pg/ml,差异均具有统计学意义(P<0.05)。结论组合型人工肾(HP联合HD)可以有效降低血液透析患者血清PTH水平。
Objective To investigate the effect of combined artificial kidney (HP) combined with hemodialysis (HD) on lowering serum parathyroid hormone (PTH) level in HD patients. Methods 34 cases of uremic patients undergoing maintenance hemodialysis were divided into study group and control group according to the digital table method, with 17 cases in each group. The study group treated with HP + HD, while the control group treated with simple HD. The changes of serum calcium, phosphorus and PTH before and after treatment were compared between the two groups. Results There was no significant difference in serum calcium, phosphorus and PTH levels between the two groups before treatment (P> 0.05). There was no significant difference in serum calcium levels between the two groups after treatment (P> 0.05), and there was no significant difference between the two groups (P> 0.05). After treatment, The differences were statistically significant (P <0.05). After treatment, the levels of serum phosphorus (1.87 ± 0.24) mmol / L and PTH (285.01 ± 27.88) pg / ml in the study group were significantly lower than those in the control group (2.47 ± 0.20 mmol / L, 310.52 ± 24.36) pg / Significance (P <0.05). Conclusion Combination artificial kidney (HP combined with HD) can effectively reduce serum PTH levels in hemodialysis patients.