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吡哌酸(Pipemidic Acid,简称PPA),对大肠杆菌、痢疾杆菌,产气杆菌,变形杆菌等有较强抗菌活性,对部分绿脓杆菌也有作用。细菌对吡哌酸和其他抗菌药物间无交叉耐药作用。口服吸收良好,投药后约二小时可达到血浓度高峰,并能广泛分布于全身,在脏器与组织中的浓度高于血浓度。在体内几乎不被代谢,一次给药能保持6小时有效浓度,最后由肾脏以药物原型排泄,尿中回收率可
Pipemidic Acid (PPA) has strong antibacterial activity against Escherichia coli, Shigella, Aerobacterium aerogenes and Proteus, and also has some effects on some Pseudomonas aeruginosa. There was no cross-resistance between pipemidic acid and other antibacterials. Oral absorption of good, about two hours after administration can reach the peak blood concentration and can be widely distributed in the body, the concentration of organs and tissues higher than the blood concentration. Almost no metabolism in the body, once administered to maintain a valid concentration of 6 hours, and finally excreted by the kidney to the drug prototype, urine recovery rate