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用硝苯碇(NFD)预防无水乙醇和幽门结扎所致大鼠胃溃疡,结果显示用药组胃溃疡指数明显低于对照组(P<0.01),对溃疡的抑制率与NFD剂量呈正相关.临床观察42例十二指肠球部溃疡(DU)患者,服用NFD 10mg,每日4次,6周后溃疡愈合27例(64.3%),总有效39例(92.9%),与对照组比较有显著差异(P<0.005).用NFD治疗胃溃疡(GU)20例.溃疡愈合15例(75.0%),总有效19例(95.0%).抗溃疡机理研究表明,NFD可减少胃液分泌量,降低胃液酸度及胃蛋白酶活性.用放免法测量大鼠胃粘膜前列腺素E_2(PGE_2)含量,在NFD组,使用乙醇1.5h及2h后,胃粘膜PGE_2含量与对照组比较;有显著增加,P分别<0.05及<0.01.本药临床疗效与西米替丁(CIM)相似,副作用小,对正常血压者用药前后血压无明显改变.该药使用方便,可望成为一种治疗消化性溃疡的新药.
Nifedipine (NFD) prevented gastric ulcer in rats induced by ethanol and pylorus ligation. The results showed that the gastric ulcer index of the treated group was significantly lower than that of the control group (P <0.01). The inhibition rate of ulcer was positively correlated with the dosage of NFD. Clinical observation of 42 patients with duodenal ulcer (DU) taking NFD 10mg 4 times a day, 6 cases of ulcer healed in 27 cases (64.3%), the total effective 39 cases (92.9%), compared with the control group There were significant differences (P <0.005) .20 cases of gastric ulcer (GU) were treated with NFD.The ulcer healed in 15 cases (75.0%), the total effective in 19 cases (95.0%) .Study on the anti-ulcer mechanism showed that NFD could reduce the secretion of gastric juice , Gastric juice acidity and pepsin activity were decreased.The contents of prostaglandin E_2 (PGE_2) in gastric mucosa were measured by radioimmunoassay, and the content of PGE_2 in gastric mucosa of NFD group was significantly increased compared with control group after treated with ethanol for 1.5h and 2h, P <0.05 and <0.01 respectively. The clinical efficacy of this drug is similar to that of cimetidine (CIM) and has few side effects and no significant change in blood pressure before and after treatment for normotensive patients. The drug is easy to use and is expected to be a potential treatment for peptic ulcer New drug