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四环素的检定方法,药物学上用微生物检定法,也有用分光光度法、色谱法。1952年以后有用极谱法的报导。Chatten等用直流极谱在硼酸底液中测定了0.01～0.125mg/ml的四环素。Olliff等在HAc-NaAc缓冲液中用交流极谱测定了2×10~(-6)～1×10~(-4)M四环素。Bard报导用微分脉冲极谱检测下限达0.2ppm。我们用直流、交流、示波和微分脉冲极谱研究了四环素在醋酸、硼酸、磷酸盐的缓冲液中的极谱行为,提高了分析灵敏度,并应用于四环素药片、软膏、眼膏和针剂中四环素含量的测定,得到满意的结果。
Tetracycline test method, pharmacological microbiology test, but also useful spectrophotometry, chromatography. Polarographic reports after 1952. Chatten et al. Determined DC at 0.01 to 0.125 mg / ml of tetracycline in DCB using DC polarography. Olliff et al. Determined 2 × 10 -6 tetanus to 1 × 10 -4 m with AC polarography in HAc-NaAc buffer. Bard reported using differential pulse polarography detection limit of 0.2ppm. We investigated the polarographic behavior of tetracycline in acetate, boric acid, phosphate buffers using DC, AC, oscillometric and differential pulse polarography to improve analytical sensitivity and to tetracycline tablets, ointments, eye ointments and injections Determination of tetracycline content, get satisfactory results.