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聚肌胞(Polyinosinic-PolycytidylieAcid、简称Polgl:C 或PIC)为人工合成的双链多聚肌胞酸。国外于1969年研制,同年我国研制成功,1976年后才逐渐用于临床,1983年以来,国内有较多的临床应用报道,被认为是一种广谱的抗病毒药,通过诱导内生性干扰素及增强肌体免疫功能,用于治疗皮肤、眼、口腔、传染等多科某些病毒性疾病,并证明有效。兹就其作用机理及临床应用情况作一综述。
Polyinosinic-Polycytidyl-Acid (referred to as Polgl: C or PIC) is a synthetic double-stranded polylysine. Abroad was developed in 1969, the same year China’s successful development, after 1976 gradually used in clinical, since 1983, there are more clinical reports, is considered a broad-spectrum antiviral drugs, by inducing endogenous interference And enhance the body’s immune function, for the treatment of skin, eyes, mouth, infections and other multi-family of certain viral diseases, and proved effective. It reviews its mechanism of action and clinical application.