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最新概念认为,进行性肌营养不良症的主要发病因素是广泛性膜缺陷.膜的生化,生物物理和形态学研究提示此病的膜功能改变不仅见于肌肉组织,而且见于红细胞.根据文献资料,现已广泛采用将红细胞作为研究膜基本运转过程特征方面的合适模型.钙促使钾流出红细胞(所谓Gardos效应)是一种特征性离子运转功能.钾选择性外流与细胞内游离钙水平升高密切相关.根据本病的肌细胞内钙自体稳定异常以及全身性膜缺陷的理论,作者观察了Duchenne氏肌营养不良病人(DMD)钙依赖性钾转移有无改变.
The latest concept that the main pathogenesis of progressive muscular dystrophy is a wide range of membrane defects.Membrane biochemical, biophysical and morphological studies suggest that changes in membrane function of the disease not only seen in muscle tissue, but also found in red blood cells.According to the literature, Erythrocytes have been widely used as a suitable model for investigating the characteristics of the membrane’s basic course of action. Calcium promotes the outflow of potassium from the erythrocytes (the so-called Gardos effect), a characteristic ionic transport function that is associated with increased intracellular free calcium levels According to the theory of myofibroblastic autonomic dysfunction and systemic membrane defects in this disease, we examined whether there was any change in calcium-dependent potassium transfer in patients with Duchenne’s muscular dystrophy (DMD).