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[目的]观察肝宁方治疗肝硬化脾功能亢进症疗效。[方法]将60例随机分为两组,肝宁方组(治疗组)和复方鳖甲软肝片组(对照组)。[结果]治疗组在改善中医症候、体征积分,尤对乏力、纳呆及大便不调等症状均较对照组为优(P<0.05);治疗后白细胞、血小板计数两组均有升高,治疗组差异显著(P<0.05),对照组不明显(P>0.05),治疗组优于对照组(P<0.05);治疗组患者门静脉内径、脾静脉内径在治疗3个月后均有明显改善(P<0.05),两组间比较差异不显著(P>0.05)。[结论]肝宁方治疗肝硬化脾功能亢进症,不但可以改善患者的中医症候、体征积分,并有升高患者血小板和白细胞作用。
[Objective] To observe the curative effect of Ganning Decoction on cirrhosis and hypersplenism. [Methods] Sixty cases were randomly divided into two groups: Gan Ning Fang group (treatment group) and Fufang Biejia Ruangan Pian group (control group). [Results] The treatment group was superior to the control group in improving TCM symptoms and signs, especially weakness, poor appetite and stool irregularity (P <0.05). After treatment, both white blood cell count and platelet count increased, (P <0.05), and the treatment group was superior to the control group (P <0.05). The diameter of the portal vein and the diameter of the splenic vein in the treatment group were all significantly increased after 3 months of treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). [Conclusion] Treatment of hepatic cirrhosis and hypersplenism by Ganning Decoction not only can improve TCM symptoms and signs of patients, but also increase platelet and leucocyte of patients.