[目的]观察三叶因子2(TFF2)在胃黏膜病变中的表达及临床意义。[方法]在浅表性胃炎、糜烂性胃炎及胃溃疡3种轻、中、重病变的胃病患者胃黏膜中测定TFF2。观察TFF2在这三个阶段的变化。[结果]TFF2的表达在浅表性胃炎中低、在糜烂性胃炎中次低,在胃溃疡中最低,病情轻重程度与TFF2的表达呈负相关。[结论]TFF2具有保护胃黏膜免受致病因素攻击的作用。 [Objective] To observe the expression of trefoil factor 2 (TFF2) in gastric mucosal lesions and its clinical significance. [Method] TFF2 was measured in the gastric mucosa of 3 mild, moderate and severe gastric lesions of superficial gastritis, erosive gastritis and gastric ulcer. TFF2 observed in these three stages of change. [Results] The expression of TFF2 was low in superficial gastritis, the second lowest in erosive gastritis, the lowest in gastric ulcer. The severity of the disease was negatively correlated with the expression of TFF2. [Conclusion] TFF2 has the effect of protecting gastric mucosa from the attack of pathogenic factors.