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Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity,while some 1,3-benzoxazine derivatives show anti-inflammatory activity.In order to explore the novel anti-inflammatory agents,based on the principles of bioisosterism and hybridization,ten novel chromeno[8,7-e][1,3]oxazin-4-ones were synthesized and characterized with IR,1H NMR,MS and elemental analyses.The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice.According to screened results,some target compounds show potent anti-inflammatory activity.
Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity, while some 1,3-benzoxazine derivatives show anti-inflammatory activity. In order to explore the novel anti-inflammatory agents, based on the principles of bioisosterism and hybridization, ten novel chromeno [8,7-e] [1,3] oxazin-4-ones were synthesized and characterized with IR, 1H NMR, MS and elemental analyzes. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, some target compounds show potent anti-inflammatory activity.