论文部分内容阅读
作为一种必需氨基酸，色氨酸(tryptophan，Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine，Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、COn 2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受体(aromatic hydrocarbon receptor，AhR)、孕烷X受体(progesterone X receptor，PXR)，诱导胰高血糖素样肽-1(glucagon like peptide-1，GLP-1)释放，改善肠道抗氧化能力及线粒体功能，促进5-HT释放等机制参与调节机体健康。这里通过阐述Trp、Trp代谢过程以及Trp代谢物的作用机制，探讨Trp及其代谢产物对肠粘膜免疫屏障的调节作用。n “,”As an essential amino acid, tryptophan(Trp) produces 5-hydroxytryptamine, niacin, COn 2, quinoline and indole derivatives through serotonin (5-HT), kynurenine (Kyn) and microbial metabolic pathway. Trp and its metabolites can regulate body health by activating aromatic hydrocarbon receptor(AhR), progesterone X receptor (PXR), inducing the release of glucagon like peptide-1 (GLP-1), improving intestinal antioxidant capacity and mitochondrial function, and promoting the release of 5-HT. In this review, we discussed the regulatory effect of Trp and its metabolites on intestinal mucosal immune barrier by elaborating the Trp, Trp metabolism and the mechanism of Trp metabolites.n