以H_3PW_(12)O_(40)/ZrO_2-WO_3为催化剂,丙酸和正丁醇为原料合成丙酸正丁酯。探讨H_3PW_(12)O_(40)/ZrO_2-WO_3对缩醛酯化反应的催化活性,较系统地研究了酸醇物质的量比、催化剂用量、反应时间等因素对产物收率的影响,实验表明:H_3PW_(12)O_(40)/ZrO_2-WO_3是合成丙酸正丁酯的良好催化剂;在n(丙酸):n(正丁醇)=1:1.4,催化剂用量占反应物量总质量的1.5%,环己烷为带水剂6ml,反应时间45min的最佳条件下,丙酸正丁酯的收率可达85.9%。 N-Butyl propionate was synthesized from propionic acid and n-butanol using H_3PW_ (12) O_ (40) / ZrO_2-WO_3 as catalyst. The catalytic activity of H_3PW_ (12) O_ (40) / ZrO_2-WO_3 on the esterification of acetal was investigated. The effects of the ratio of the amount of acid to alcohol, the amount of catalyst and the reaction time on the yield of the product were systematically studied. The results show that H_3PW_ (12) O_ (40) / ZrO_2-WO_3 is a good catalyst for the synthesis of n-butyl propionate; the amount of catalyst in n (n-butanol) = 1: 1.5% cyclohexane with water agent 6ml, the optimal reaction time 45min, n-butyl propionate yield up to 85.9%.