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目的探讨可溶性CD146(sCD146)与可溶性血管细胞黏附分子-1(sVCAM-1)在过敏性紫癜(HSP)患儿血浆中的表达水平及临床意义。方法采用ELISA法检测HSP患儿(急性期42例、缓解期39例)及健康对照组儿童(30例)外周血浆sCD146、sVCAM-1水平,比较HSP患儿急性期、缓解期和健康对照组之间的差异以及急性期肾脏受累组、无肾脏受累组之间的差异,并对HSP患儿急性期血浆sCD146与sVCAM-1水平进行相关性分析。应用SPSS 13.0软件进行统计学处理。结果 HSP患儿急性期sCD146、sVCAM-1水平明显高于缓解期和健康对照组,差异均有统计学意义(Pa<0.01);缓解期sCD146水平仍高于健康对照组,差异有统计学意义(P<0.01),缓解期sVCAM-1水平与健康对照组比较差异无统计学意义(P>0.05);急性期肾脏受累组sCD146、sV-CAM-1水平高于无肾脏受累组,差异均有统计学意义(Pa<0.01);HSP患儿急性期血浆sCD146与sVCAM-1水平呈正相关(r=0.79,P<0.01)。结论 sCD146与sVCAM-1在HSP和紫癜性肾炎的发生发展中起重要作用。动态监测HSP患儿血浆sCD146、sVCAM-1水平对于判定其病情发展及预后有一定意义。
Objective To investigate the expression of soluble CD146 (sCD146) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in plasma of children with Henoch-Schonlein purpura (HSP) and its clinical significance. Methods The levels of sCD146 and sVCAM-1 in peripheral blood were detected by ELISA in 42 children with acute HSP (42 in acute phase, 39 in remission) and 30 healthy children (control group) And the difference between the acute renal involvement group and the non-renal involved group. The correlation between plasma sCD146 and sVCAM-1 levels in the acute stage of HSP was analyzed. Application SPSS 13.0 software for statistical analysis. Results The levels of sCD146 and sVCAM-1 in acute stage of HSP were significantly higher than those in remission stage and healthy control group (P <0.01). The sCD146 level in remission stage was still higher than that of healthy control group, the difference was statistically significant (P <0.01). The level of sVCAM-1 in remission stage was not significantly different from that in healthy control group (P> 0.05). The levels of sCD146 and sV-CAM-1 in renal involvement group were higher than those without renal involvement (P <0.01). There was a positive correlation between the level of sCD146 and sVCAM-1 in acute stage of HSP (r = 0.79, P <0.01). Conclusion sCD146 and sVCAM-1 play an important role in the development of HSP and purpuric nephritis. Dynamic monitoring of HSP in children with plasma sCD146, sVCAM-1 levels for the determination of its disease progression and prognosis of a certain significance.