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小鼠骨髓染色体畸变试验是一种检测环境诱变剂的短期试验。日本等国已作为常规试验方法。实验设计一般设三个剂量组和一个对照组,按照急性毒性试验得出的最大耐受量或1/5LD_(50)作为最大剂量组,最小剂量按毒性大小进行估计,目的是得出最大无作用剂量。二组间设一中间剂量。按受试物实际进入人体的途径选择给药途径。急性试验一次给药,亚急性连续五天,慢性可连续给药三个月。
Mouse bone marrow chromosome aberration test is a short-term test for detecting environmental mutagens. Japan and other countries have been used as a routine test method. The experimental design is generally divided into three dose groups and one control group. According to the acute toxicity test, the maximum tolerable dose or the 1 / 5LD_ (50) is the maximum dose group, and the minimum dose is estimated according to the toxicity, so as to obtain the maximum The role of dose. Between the two groups set an intermediate dose. According to the actual test substance into the body to choose the route of administration. Acute experimental administration, subacute five consecutive days, chronic continuous administration for three months.