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选用32只(64后肢)体重在11～18.5kg成年健康杂种狗,随机分为三组,每组10～11只。实验组将血管束植入源于肋骨、胫骨段的骨块内,并埋置肌间,对侧骨为无血管束植入的对照组。术后60～180天作大体观测、X线检查和组织学观察。在半数动物作骨缺血坏死模型实验的骨块,采用热灼法、蒸煮游离骨和硅膜包骨法,在不同时间内进行观察,其中以硅膜包骨的骨缺血坏死模型最为满意。实验证明,在血管束植入骨内后,可以重建血供,血管长入,骨细胞再生,发现有很多密集的成骨细胞、骨软骨母细胞、胶原纤维、新骨小梁和黄骨髓等组织,而无血管束植入的对照骨块均成为死骨。
32 healthy adult dogs (64 hindlimbs) weighing 11 ~ 18.5 kg were randomly divided into three groups (n = 10 to 11). In the experimental group, the vascular bundles were implanted into the bones of the ribs and tibia segments, and the interosseous bones were embedded. The contralateral bone was a control group without vascular bundles implantation. After 60 to 180 days for general observation, X-ray examination and histological observation. In half of the animal models of osteonecrosis and necrosis, the bone fragments were observed at different times by thermal burning method, cooking free bone and silicon film sling method, among which the most satisfactory bone osseous necrosis model was silicon suture. Experiments show that, after implantation of vascular bundles within the bone, you can rebuild the blood supply, vascular growth, regeneration of bone cells, found a lot of intensive osteoblasts, osteochondroblasts, collagen fibers, new trabecular bone and yellow bone marrow Tissues without vascular bundle implantation became the sequestrum.