日本的研究者已鉴定出对氨基糖苷类的新的耐药机制,在铜绿假单胞菌中对所有临床有效的氨基糖苷类均显示高水平耐药。1997年从临床样品中分离出了铜绿假单胞菌AR2。研究者克隆并测定了耐药基因,把氨基糖苷耐药基因称为rmtA ,该基因可编码与16SrRNA甲基化酶非常相似的蛋白质。在 Japanese researchers have identified new mechanisms of resistance to aminoglycosides that show high levels of resistance to all clinically effective aminoglycosides in P. aeruginosa. Pseudomonas aeruginosa AR2 was isolated from clinical samples in 1997. The researchers cloned and sequenced the drug-resistant gene, which calls the aminoglycoside resistance gene rmtA, which encodes a protein that is very similar to 16SrRNA methylase. in