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目的探讨新诊断2型糖尿病早期短程胰岛素强化治疗的疗效。方法对新诊断2型糖尿病患者予以短程胰岛素泵强化治疗,观察疗程前后Hom aβ胰岛素分泌指数,血糖控制情况以及对2型糖尿病早期病程的逆转。结果短程胰岛素强化治疗后控制了高血糖并显著提高了Hom aβ胰岛素分泌指数,使大部分患者恢复到2型糖尿病自然病程的更早阶段。结论短期胰岛素强化治疗对于新诊断的2型糖尿病患者,能够最及时有效地控制高血糖并改善胰岛功能,使大部分患者获得长时间无需药物治疗的血糖稳定期,是治疗的首选方案之一。
Objective To explore the effect of early diagnosis of type 2 diabetes with early short-term insulin-intensive therapy. Methods Patients with newly diagnosed type 2 diabetes were treated with short-term insulin pump intensive therapy. Hom α secretion index, glycemic control and reversal of early stage of type 2 diabetes were observed before and after treatment. Results Short-term intensive insulin treatment controlled hyperglycemia and significantly increased Hom α-insulin secretion index, leaving most patients to return to an earlier stage of natural history of type 2 diabetes. Conclusions Short-term intensive insulin therapy is the first choice of treatment for patients with newly diagnosed type 2 diabetes who can control hyperglycemia and improve islet function most promptly and effectively, so that most patients get long-term glucose-stable period without drug treatment.