应用可见光光度计,测定了200名藏族健康志愿者一次口服磺胺二甲嘧啶[Sulfadimidine]2g,4小时内尿样中乙酰化磺胺与末代谢磺胺二甲嘧啶比值。结果表明受试者磺胺二甲嘧啶乙酰化代谢具双态性。频数分布曲线有两个较明显的波峰,第一波峰在40～45％处,第二波峰在70～75％处。提示有两个亚群。因此,我们认为以55％为界分为快、慢两型为宜。凡SM_2乙酰化率小于55％者为慢型,60人(占30％),大于55％者为快型,140人(占70％)。 A total of 200 Tibetan healthy volunteers were enrolled in this study. The oral administration of 2 g sulfadiazidine was given orally. The ratio of acetylated sulfonamides to the last sulfamethazine within 4 hours was determined. The results show that the subjects sulfamethazine acetylation metabolinism. The frequency distribution curve has two obvious peaks, the first peak at 40 ~ 45%, the second peak at 70 ~ 75%. Prompts for two subgroups. Therefore, we think 55% is divided into fast and slow type is appropriate. Where SM_2 acetylation rate is less than 55% for the slow type, 60 (30%), more than 55% were fast type, 140 (70%).