本文采用豚鼠为实验模型,经吸烟一定时间后,以肺灌洗技术获取肺巨噬细胞和肺灌洗液进行检测,实验结果如下:第一,吸烟组肺灌洗液中肺巨噬细胞数明显增多,且死细胞数较正常对照为多。第二,吸烟对肺巨噬细胞之吞噬和杀菌功能有明显抑制作用。第三,吸烟对肺灌洗液中的溶菌酶水平亦有抑制和减低作用,而对5-羟色胺的水平则有刺激升高作用。 In this paper, Guinea pigs as the experimental model, after smoking for a certain period of time, lung lavage technology to obtain lung macrophages and lung lavage fluid detection, the experimental results are as follows: First, smoking lung lavage fluid in the number of lung macrophages Significantly increased, and more dead cells than normal controls. Second, smoking has a significant inhibitory effect on phagocytosis and bactericidal activity of pulmonary macrophages. Third, smoking on lung lavage fluid lysozyme levels also inhibit and reduce the role of the serotonin levels have a stimulating effect.