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吡哌酸口服吸收迅速、完全,1h可达治疗浓度,1次服药可维持疗效4～6h。体内分布以肝、肾最高,肺、眼球低于血液。按原型自肾、胆排出。尿、胆汁、粪便内含量较血液高100～200倍。毒副反应轻微。本品对革兰阴性菌效果较好。大肠杆菌、变形杆菌、痢疾杆菌、沙门氏菌、流感杆菌、E1 Tor弧菌、流脑双球菌的最低抑菌浓度为1.56～3.12μg/ml,浓度提高1倍,可直接杀灭细菌。但对革兰阳性菌的敏感性较差。临床用于治疗肠道、泌尿和胆系急慢性感染。
Pipemidic acid oral absorption quickly, completely, 1h up to the treatment concentration, 1 dose can maintain the efficacy of 4 ~ 6h. Distribution of the body to the liver, kidney, lung, eye below blood. According to the prototype from the kidney, gallbladder discharge. Urine, bile, stool content higher than the blood 100 to 200 times. Toxicity minor. This product is good for gram-negative bacteria. The minimum inhibitory concentrations of Escherichia coli, Proteus, Shigella, Salmonella, Influenzae E1, Vibrio meningitidis were 1.56 ~ 3.12μg / ml and the concentration was doubled, which could directly kill bacteria. But less sensitive to Gram-positive bacteria. Clinical for the treatment of intestinal, urinary and gall bladder acute and chronic infections.