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[目的]观察养血通脉汤联合甲磺酸倍他司汀治疗椎-基底动脉供血不足性眩晕疗效。[方法]使用随机平行对照方法,将72例门诊患者按抛硬币法简单随机分为两组。对照组36例甲磺酸倍他司汀,12mg/次,3次/d。治疗组36例养血通脉汤(鸡血藤30g,枸杞12g,天麻、川芎、丹参各15g,泽泻12g,首乌、黄芪各15g,姜半夏各12g,葛根、钩藤各15g,枣皮12g),1剂/d,水煎400mL,早晚口服;甲磺酸倍他司汀治疗同对照组。连续治疗21d为1疗程。观测临床症状、椎动脉血流图、脑电图、纤维蛋白原、全血黏度、红细胞比积、血浆黏度、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈23例,显效9例,有效3例,无效1例,总有效率97.22%;对照组痊愈12例,显效3例,有效15例,无效6例,总有效率8233%;治疗组疗效优于对照组(P<0.05)。纤维蛋白原、全血黏度、红细胞比积、血浆黏度治疗组改善优于对照组(P<0.01)。[结论]养血通脉汤联合甲磺酸倍他司汀治疗椎-基底动脉供血不足性眩晕疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Yangxue Tongmai soup combined with betahistine mesylate on vertebrobasilar insufficiency vertigo. [Method] Using random parallel control method, 72 outpatients were randomly divided into two groups according to the coin-tossing method. The control group 36 patients received betahistine mesylate, 12mg / time, 3 times / d. The treatment group of 36 cases of Yangxue Tongmai soup (Millettia 30g, Chinese wolfberry 12g, Tianma, Chuanxiong, Salvia 15g, Alisma 12g, Radix, Astragalus 15g, ginger Pinellia each 12g, Radix, 15g Uncaria, jujube 12g), 1 / d, decoction 400mL, sooner or later orally; betahistine mesylate treatment with the control group. Continuous treatment of 21d for a course of treatment. Clinical symptoms, vertebral artery blood flow diagram, EEG, fibrinogen, whole blood viscosity, hematocrit, plasma viscosity and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 23 cases were cured, 9 cases were markedly effective, 3 cases were effective, 1 case was ineffective and the total effective rate was 97.22%. In the control group, 12 cases were cured, 3 cases markedly effective, 15 effective and 6 ineffective. The total effective rate was 8233% The treatment group was better than the control group (P <0.05). Fibrinogen, whole blood viscosity, hematocrit, and plasma viscosity improved better than the control group (P <0.01). [Conclusion] Yangxue Tongmai soup combined with betahistine mesylate in treatment of vertebrobasilar insufficiency vertigo has satisfactory curative effect and no serious adverse reactions, which is worth to be popularized.