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临床证据检索和评价截止至 2 0 0 2年 3月。结果 :⑴硬化性苔癣 :①口服视黄醛 (阿维A) :1个小样本RCT经过 2 0～ 2 2周随访发现 ,阿维A与安慰剂相比 ,能显著减轻瘙痒和减小病变程度 ,但与严重的脱皮、脱发有关。②外科手术 :我们未找到手术治疗妇女硬化性苔癣疗效的充足证据。③局部用 0 0 5 %丙酸氯倍他索 (又名氯氟美松 ) :1个小样本RCT经过 3个月的治疗发现 ,局部用丙酸氯倍他索比局部用丙酸睾丸酮或矿物油软膏能更有效地控制症状。高质量的前瞻性观察性研究发现 ,丙酸氯倍他索用于维持治疗时副作用轻微。④局部用睾丸酮 :2个小样本RCT认为 ,不管是用于 12个月的初始治疗 ,还是在用了丙酸氯倍他索 16周后的继续治疗 ,都没有证据证明丙酸睾丸酮比矿物油软膏更能缓解症状。丙酸睾丸酮与男性化有关。⑵外阴上皮内瘤样病变 :我们发现 ,外阴上皮内瘤样病变的外科手术治疗效果和局部应用α 干扰素治疗效果 ,目前临床证据不足。
Clinical evidence retrieval and evaluation ended in March 2002. ⑴ sclerosing lichen planus: ① oral retinal (Avi A): a small sample of RCT after 20 ~ 2 2-week follow-up found that Avi A and placebo can significantly reduce itching and reduce Degree of disease, but with serious peeling, hair loss. ② Surgery: We have not found sufficient evidence of efficacy of surgical treatment of scleroses in women. (3) topical 0 0 5% clobetasol propionate (also known as clomethasone): a small sample RCT after 3 months of treatment found that topical with clobetasol propionate than with testosterone propionate or Mineral oil ointment to more effectively control the symptoms. High-quality, prospective, observational studies have found mild side effects of clobetasol propionate in maintenance therapy. Topical testosterone: two small samples RCT believes there is no evidence that testosterone propionate is more effective than mineral oil in either initial treatment for 12 months or continued treatment with clobetasol propionate after 16 weeks Ointment can relieve symptoms more. Testosterone propionate and masculine. ⑵ vulvar intraepithelial neoplasia: We found that the surgical treatment of vulvar intraepithelial neoplasia lesions and local application of interferon alpha treatment, the current clinical evidence is not enough.