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目的观察抗焦虑抑郁药及心理疏导辅助治疗功能性消化不良(FD)的疗效。方法选择46例符合罗马Ⅱ诊断标准、伴有焦虑抑郁状态的FD患者。用Zung焦虑自评量表和抑郁自评量表评定患者心理情绪状态。随机分为黛力新组和对照组。黛力新组给予多潘立酮10mg/次,3次/d,加用抗焦虑抑郁药黛力新,每日晨1片,辅以心理疏导,疗程4周;对照组仅用多潘立酮。比较两组治疗后症状改善情况。结果治疗后黛力新组消化不良症状改善总有效率为82.61%,对照组为43.70%,有显著性差异(P﹤0.01);黛力新组治疗后焦虑量表评分和抑郁量表评分均明显低于治疗前(P均﹤0.05),治疗后黛力新组两种量表评分均低于对照组(P均﹤0.05)。结论对伴有焦虑抑郁状态的FD患者加用抗焦虑抑郁药治疗及心理疏导,效果优于单纯使用多潘立酮者;FD发病可能与精神心理因素有关。
Objective To observe the efficacy of anti-anxiety depression drugs and psychological counseling in the treatment of functional dyspepsia (FD). Methods Forty-six FD patients who met the diagnostic criteria of Rome Ⅱ and had anxiety and depression status were selected. Zung anxiety self-rating scale and depression self-rating scale to assess the patient’s emotional state. Randomly divided into Deanxit new group and control group. Deanxit new group given domperidone 10mg / time, 3 times / d, with anti-anxiety depression drug Deanxu, daily morning 1, supplemented by psychological counseling, treatment for 4 weeks; the control group only domperidone. The symptoms of the two groups were compared after treatment. Results After treatment, the total effective rate of dyslipidemia was 82.61% in retina group and 43.70% in control group (P <0.01). The scores of anxiety scale and depression scale in both groups after treatment (P <0.05). After treatment, the two kinds of scale of Deanxit group were lower than those of the control group (all P <0.05). Conclusions The treatment of FD patients with anxiety and depression with anti-anxiety depression drug and psychological counseling are better than those with only domperidone. The incidence of FD may be related to mental and psychological factors.