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阿司匹林(又名醋柳酸、乙酰水杨酸)是一个非固醇类解热镇痛药,1899年开始应用于临床。近10年来,随着对前列腺素研究的突破,阿司匹林的药理机制逐渐有所新认识,其用途也越来越广。下面简单介绍一下阿司匹林的新认识。随着前列腺素(以下简称PG)研究的发展,70年代初人们已发现阿司匹林与PG有密切的关系,在豚鼠肺织组匀浆从花生四烯酸合成PGE_2和PGF2a的实验里,6.3微克/毫升的阿斯匹林就能使PGF2a的合成减半,这是一个很小的浓度,肯定在药物治疗剂量的血浆浓度
Aspirin (also known as acetic acid, acetylsalicylic acid) is a non-steroidal antipyretic analgesic, 1899 began to be used clinically. In the past 10 years, with the breakthrough of prostaglandin research, the pharmacological mechanism of aspirin gradually gained some new understanding and its use is also more and more widely. The following brief introduction of new understanding of aspirin. With the development of prostaglandin (PG) research, in the early 1970s, it was found that aspirin has a close relationship with PG. In the experiment of homogenizing guinea pig lung tissue with PGE 2 and PGF 2 a from arachidonic acid, 6.3 μg / Ml of aspirin can halve the synthesis of PGF2a, which is a very small concentration, certainly at the plasma drug concentration