目的:通过研究狼疮性肾炎患者血清超敏C反应蛋白水平与左心室肥厚的关系,探讨炎症在狼疮性肾炎左心室肥厚发生中的作用。方法:对287例系统性红斑狼疮、狼疮性肾炎患者的临床病史、生化检查、免疫学指标、血清超敏C反应蛋白及心脏超声结果进行统计分析。结果:287例患者中,左心室肥厚的发生率为78.75%(n=226)。存在左心室肥厚的患者年龄较大[(40.92±14.16)岁vs(35.43±11.88)岁]、血清超敏C反应蛋白水平[8.03(3.22～30.95)mg/Lvs3.93(1.48～9.48)mg/L]及血尿酸水平[(491.78±29.35)μmol/Lvs(402.44±17.03)μmol/L]明显升高,而血红蛋白[(90.62±22.99)g/Lvs(105.95±22.43)g/L]及肾小球滤过率[(66.05±4.68)ml.min-1.1.73m-2vs(90.24±4.52)ml.min-1.1.73m-2]显著降低。相关分析结果发现左心室重量指数与超敏C反应蛋白水平呈正相关(r=0.314,P<0.01),而多元回归分析结果进一步证实超敏C反应蛋白水平是左心室重量指数的独立危险因素(β=0.338,P<0.01)。结论:狼疮性肾炎患者心血管并发症发生率较高,超敏C反应蛋白水平与左心室重量指数呈正相关并且是其独立危险因素,提示炎症对狼疮性肾炎患者左心室肥厚的发生发展可能起重要作用,积极干预这些危险因素对于防治狼疮性肾炎患者的心血管并发症具有重要意义。 OBJECTIVE: To investigate the role of inflammation in the development of left ventricular hypertrophy in patients with lupus nephritis by studying the relationship between serum high-sensitivity C-reactive protein and left ventricular hypertrophy in patients with lupus nephritis. Methods: The clinical data of 287 patients with systemic lupus erythematosus and lupus nephritis, biochemical tests, immunological indexes, serum high-sensitivity C-reactive protein and echocardiography were analyzed statistically. Results: Of the 287 patients, the incidence of left ventricular hypertrophy was 78.75% (n = 226). Patients with left ventricular hypertrophy were older (40.92 ± 14.16 vs 35.43 ± 11.88 years), and serum levels of high-sensitivity C-reactive protein 8.03 (3.22-30.95) mg / L vs 3.93 (1.48-9.48) mg / L] and serum uric acid levels [(491.78 ± 29.35) μmol / L vs (402.44 ± 17.03) μmol / L] and hemoglobin [(90.62 ± 22.99) g / L vs Glomerular filtration rate [(66.05 ± 4.68) ml.min-1.1.73m-2vs (90.24 ± 4.52) ml.min-1.1.73m-2] was significantly reduced. Correlation analysis revealed a positive correlation between left ventricular mass index and high-sensitivity C-reactive protein (r = 0.314, P <0.01). Multiple regression analysis further confirmed that high-sensitivity C-reactive protein was an independent risk factor for left ventricular mass index β = 0.338, P <0.01). Conclusions: The incidence of cardiovascular complications in patients with lupus nephritis is high, and the level of high sensitivity C-reactive protein is positively correlated with left ventricular mass index, which is an independent risk factor. It suggests that the occurrence and development of left ventricular hypertrophy may play an important role in the pathogenesis of lupus nephritis The important role of active intervention of these risk factors for the prevention and treatment of cardiovascular complications in patients with lupus nephritis is of great significance.