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[目的]探讨薄层液基细胞学(TCT)、人乳头状瘤病毒(HPV)检测在宫颈病变诊断中的价值。[方法]2007年11月至2008年3月280例患者行TCT、HPV亚型检测以及阴道镜下宫颈活检,以阴道镜下病理结果为标准,分析TCT、HPV检测对宫颈病变诊断的准确率。[结果]TCT及HPV检测两者之一阳性的78例患者中,病理学诊断为CIN及宫颈癌20例,检出率25.64%(20/78);两者检测均阴性者,CIN检出率0.49%(1/202);两者检测均阳性者,CIN及宫颈癌检出率61.54%(16/26)。两者之一检测阳性组CIN及宫颈癌检出率显著性高于两者检测均阴性组(χ2=42.88,P<0.01)。TCT检测阳性42例中,CIN及宫颈癌18例,检出率42.86%(18/42);HPV检测阳性62例中,CIN及宫颈癌检出率29.03%(18/62)。[结论]无创性的TCT、HPV检测是宫颈阴道镜活检的有效补充,个体化应用于宫颈癌前病变及宫颈癌的检测有一定临床价值。
[Objective] To investigate the value of thin-section liquid-based cytology (TCT) and human papillomavirus (HPV) detection in the diagnosis of cervical lesions. [Methods] 280 cases of patients with TCT, HPV subtypes and colposcopic biopsy from November 2007 to March 2008 were analyzed. The accuracy of TCT and HPV testing in diagnosis of cervical lesions was analyzed by colposcopy. . [Results] Of the 78 patients with positive TCT or HPV test, 20 cases were diagnosed as CIN and cervical cancer by pathology, the detection rate was 25.64% (20/78). When both of them were negative, CIN was detected The rate was 0.49% (1/202). The positive rates of both CIN and cervical cancer were 61.54% (16/26). The positive rate of CIN and cervical cancer was higher in the positive group than in the negative group (χ2 = 42.88, P <0.01). Of 42 cases with positive TCT, CIN and cervical cancer were detected in 18 cases (42.86%, 18/42). Of the 62 HPV positive cases, the positive rate of CIN and cervical cancer was 29.03% (18/62). [Conclusion] Noninvasive detection of TCT and HPV is an effective supplement for cervical colposcopy biopsy. It has some clinical value for individual detection of cervical precancerous lesions and cervical cancer.