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非甾体类抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)是一类解热、镇痛、抗炎的药物,广泛应用于临床,按化学结构的不同,可以分为水杨酸类、苯胺类、吡唑酮类及其他有机酸4类,通过阻断前列腺素(prostaglandins,PGs)的合成,从而实现抗炎、止痛、解热的作用[1]。近年通过流行病学、动物模型及临床应用的研究均表明NSAIDs能够通过诱导肿瘤细胞的凋亡、抑制肿瘤的侵袭和转移而发挥抗肿瘤的作用。
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of antipyretic, analgesic, anti-inflammatory drugs, widely used in clinical, according to the different chemical structure, can be divided into salicylic acid, aniline Class 4, pyrazolones and other organic acids, through the inhibition of prostaglandins (PGs) synthesis, in order to achieve anti-inflammatory, analgesic, antipyretic effect [1]. In recent years, epidemiological, animal models and clinical application studies have shown that NSAIDs can exert anti-tumor effect by inducing tumor cell apoptosis, inhibiting tumor invasion and metastasis.