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目的探讨乌司他汀联合生长抑素治疗重症急性胰腺炎的临床疗效。方法 57例重症急性胰腺炎患者随机分为对照组28例和观察组29例。在禁食、胃肠减压、质子泵抑制剂或H2受体阻滞剂、维持水电解质酸碱平衡、止痛、营养支持、抗生素应用等常规治疗的基础上,对照组静脉注射生长抑素250μg,后用3000μg加入500m l 0.9%NaC l注射液中静脉滴注,连续7~14d;观察组乌司他汀20U加入5%葡萄糖500m l静脉滴注,b id;同时生长抑素0.1mg,1次/8h皮下注射,连用10~14d。结果对照组重症急性胰腺炎的有效率为60.71%,观察组为93.10%。结论乌司他汀联合生长抑素治疗组的临床疗效明显优于单纯使用生长抑素组,值得临床广泛推广。
Objective To investigate the clinical efficacy of ulinastatin and somatostatin in the treatment of severe acute pancreatitis. Methods Fifty-seven patients with severe acute pancreatitis were randomly divided into control group (28 cases) and observation group (29 cases). In the fasting, gastrointestinal decompression, proton pump inhibitors or H2 receptor blockers, to maintain the acid-base balance of water and electrolyte, analgesic, nutritional support, antibiotics and other conventional treatment based on the control group intravenous somatostatin 250μg , Followed by 3000μg added 500ml 0.9% NaC l injections intravenously for 7 ~ 14d; observed group of ulinastatin 20U with 5% glucose 500ml intravenous infusion, id; at the same time somatostatin 0.1mg, 1 Times / 8h subcutaneous injection, once every 10 ~ 14d. Results In the control group, the effective rate of severe acute pancreatitis was 60.71% and that of the observation group was 93.10%. Conclusion The clinical efficacy of combination of ulinastatin and somatostatin is superior to that of somatostatin alone. It is worth widely clinical application.