用 Ehrlich 腹水癌细胞为肿瘤模型,利用电镜细胞化学方法研究了二甲基甲酰胺对 Ehrlich 腹水癌细胞分化诱导作用,观察了癌细胞表面微绒毛及蛋白多糖的变化。结果表明,Ehrlich 腹水癌细胞在二甲基甲酰胺分化诱导下,细胞表面微绒毛减少或变短,同时细胞表面微绒毛区和非微绒毛区的蛋白多糖也有不同程度的减少。 Using Ehrlich ascites carcinoma cells as a tumor model, electron microscopy cytochemistry was used to study the effect of dimethylformamide on the differentiation induction of Ehrlich ascites carcinoma cells, and the changes of microvilli and proteoglycans on the surface of cancer cells were observed. The results showed that the microvilli on the cell surface of Ehrlich ascites carcinoma cells were reduced or shortened when dimethylformamide was induced to differentiate, and the proteoglycans in the microvilli and non-microvilli regions on the cell surface were also reduced to varying degrees.