论文部分内容阅读
60年代末期以来,短小棒杆菌做为非特异性免疫治疗已有大量报导。它不仅对抗原性肿瘤有较强的作用,而且对非抗原性肿瘤及弱抗原性肿瘤亦有效。在试验性肿瘤中有很好的抗肿瘤作用。材料和方法:有组织病理学诊断的各期鼻咽癌、口咽癌、T_3、T_4、N_(.3),声门上癌和梨状窝癌57例,随机分成四组。每个病人都有完整的病历、体检结果及名种实验性检查材料。有变态反应及免疫性疾患、晚期心血管病者均被除外。照射前颈部皮下或淋巴结内注射短棒4 mg/m~2接着照射前10天、7天、3天和照射后7天、14天静脉内分别注射2、2、4、4、4 mg/m~2。照射剂量大多在6500～7500rad 之间T_3,T_4、N_(0-3),的声门上癌和梨状窝癌给予4000rad 后4—6周做根治性手术对照组与控制组之间在剂量上差别很小治疗结果除使用生存率外还有无病存活时间。
Since the late 60s, there have been numerous reports of non-specific immunotherapy with Corynebacterium parvum. It not only has a strong effect on antigenic tumors, but also is effective on non-antigenic tumors and weak antigenic tumors. It has a good anti-tumor effect in experimental tumors. Materials and Methods: There were 57 cases of nasopharyngeal carcinoma, oropharyngeal carcinoma, T_3, T_4, N_(.3), supraglottic carcinoma, and pyriform sinus carcinoma diagnosed by histopathology. They were randomly divided into four groups. Each patient has a complete medical record, physical examination results, and experimental test materials of the same type. Allergic and immunological disorders, advanced cardiovascular disease were excluded. The injection of short rod 4 mg/m~2 in the subcutaneous or lymph node of the front neck before irradiation followed by 10, 7, and 3 days before irradiation, and 7, 2, 4 and 4 mg intravenously respectively 7 days and 14 days after irradiation /m~2. Most of the irradiation doses were between 6500 and 7500rad T_3, T_4, N_(0-3), supraglottic and pyriform squamous cell carcinomas were administered 4000rad 4 to 6 weeks after radical surgery between the control and control groups at doses There is a small difference in treatment outcomes, in addition to survival rates, and disease-free survival.