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目的研究血管内皮生长因子在常见恶性消化道肿瘤患者血清中的水平及其临床意义。方法应用酶联免疫吸附法(ELISA)检测210例恶性消化道肿瘤患者及87例对照者血清中血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)水平。结果肿瘤患者血清VEGF平均水平为201ng/L.对照组为76.21ng/L,两组差别有统计学意义(P<0.001);有负荷组患者血清VEGF水平高于无负荷组(P<0.001)。血清VEGF水平与肿瘤分化程度、浸润深度和临床分期密切相关(P<0.01),但与患者年龄、性别无关(P>0.05)。肿瘤患者血清VEGF水平随着KPS评分的降低,而逐渐升高(P<0.05)。结论VEGF作为一个促进血管渗透性和促进血管内皮生长的主要因子,在肿瘤发生、生长和转移过程中起着极其重要的作用,并可作为判断恶性肿瘤患者术后有无复发或转移的良好指标,在临床上具有重要的参考价值。
Objective To study the level of serum vascular endothelial growth factor in patients with common malignant gastrointestinal cancer and its clinical significance. Methods The serum levels of vascular endothelial growth factor (VEGF) in 210 patients with malignant gastrointestinal cancers and 87 controls were detected by enzyme-linked immunosorbent assay (ELISA). Results The mean serum VEGF level was 201 ng/L in tumor patients and 76.21 ng/L in control group (P<0.001). Serum VEGF levels in patients with stress were higher than those in non-stress group (P<0.001). . Serum VEGF levels were closely related to tumor differentiation, depth of invasion, and clinical stage (P<0.01), but were not related to age or gender (P>0.05). Serum VEGF levels in patients with cancer gradually increased with the decrease of KPS score (P<0.05). Conclusion VEGF is a major factor in promoting vascular permeability and promoting vascular endothelial growth. It plays an extremely important role in tumorigenesis, growth and metastasis, and it can be used as a good indicator to judge whether there is recurrence or metastasis after operation in patients with malignant tumors. , It has important reference value in clinical practice.