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目的:探讨血清转化生长因子(TGF-β1)及β2微球蛋白(β2-MG)水平对妊娠期高血压疾病(HDCP)早期肾损伤诊断的临床意义,以提高母婴的健康水平。方法:采用现况调查的研究方法,对2007年1～12月在唐山市妇幼保健院进行待产的HDCP孕妇和正常孕妇的血清TGF-β1、β2-MG、ALB、尿素氮、肌酐和尿酸水平进行分析。资料用Excel建库,用SPSS 11.5统计软件进行分析。结果:HDCP组孕妇血清TGF-β1和β2-MG水平分别为(28.51±5.63)ng/ml和(3.78±0.82)μg/ml,明显高于正常妊娠组〔分别为(19.97±4.47)ng/ml和(1.47±0.67)μg/ml〕,差异均有统计学意义(P<0.001);HDCP组孕妇ALB水平〔(33.27±4.97)mg/L〕明显低于正常妊娠组〔(37.05±2.56)mg/ml〕,差异有统计学意义(P<0.001);HDCP组孕妇尿素氮、肌酐和尿酸水平均明显高于正常妊娠组,差异有统计学意义(P<0.001);HDCP组孕妇血清TGF-β1和β2-MG水平与ALB、尿素氮、肌酐及尿酸水平呈正相关。结论:血清TGF-β1及β2-MG水平对HDCP早期肾损伤诊断具有临床意义,可用于HDCP肾损伤的预测、预防和治疗。
Objective: To investigate the clinical significance of serum transforming growth factor (TGF-β1) and β2-microglobulin (β2-MG) in the diagnosis of early renal damage in hypertensive disorder of pregnancy (HDCP) and to improve the health of maternal and infant. Methods: The levels of TGF-β1, β2-MG, ALB, blood urea nitrogen, creatinine and uric acid in HDCP pregnant women and normal pregnant women undergoing maternal and childbirth in Tangshan MCH from January to December 2007 were measured. Analyze. Information database using Excel, SPSS 11.5 statistical software for analysis. Results: Serum levels of TGF-β1 and β2-MG in HDCP group were (28.51 ± 5.63) ng / ml and (3.78 ± 0.82) μg / ml, respectively, which were significantly higher than those in normal pregnancy group (19.97 ± 4.47 ng / ml and (1.47 ± 0.67) μg / ml〕, the difference was statistically significant (P <0.001). The level of ALB in HDCP group was significantly lower than that in normal pregnancy group (33.05 ± 2.56 vs 33.27 ± 4.97 mg / L〕 ) mg / ml], the difference was statistically significant (P <0.001). The levels of serum urea nitrogen, creatinine and uric acid in HDCP group were significantly higher than those in normal pregnancy group (P <0.001) TGF-β1 and β2-MG levels and ALB, urea nitrogen, creatinine and uric acid levels were positively correlated. Conclusion: Serum levels of TGF-β1 and β2-MG are of clinical significance for the diagnosis of HDCP in early stage of renal injury, which can be used in the prediction, prevention and treatment of HDCP renal injury.