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近几年来的研究表明，ＮＡＮＣ神经元内存在ＮＯ合成酶系，刺激神经后有ＮＯ的释放，外源性ＮＯ可产生同电刺激ＮＡＮＣ神经相似的反应，同时使用ＮＯ合成抑制剂可阻断电刺激ＮＡＮＣ神经后的反应。所有这些实验资料一致说明ＮＯ是ＮＡＮＣ神经的一种抑制性神经递质。ＮＯ在人和哺乳动物的消化道内广泛分布，对胃肠道平滑肌的正常运动起着调节作用，并与胃肠疾病、肝硬化的形成有关，因而可能具有重要的临床意义。
In recent years, studies have shown that NO synthase enzyme exists in NANC neurons to stimulate the release of NO after the nerve, exogenous NO can produce NANC nerve stimulation similar to the reaction, while the use of NO synthesis inhibitors can block the electricity Response to NANC nerve stimulation. All of these experimental data consistently show that NO is an inhibitory neurotransmitter of the NANC nerve. NO is widely distributed in the digestive tract of humans and mammals and plays a regulatory role in the normal movement of the gastrointestinal smooth muscle and is associated with the formation of gastrointestinal diseases and cirrhosis and may therefore have important clinical implications.