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【目的】观察危重患儿在血压增高时微循环和凝血功能的变化,为治疗提供依据。【方法】抽取本院住院危重新生儿血压增高的患儿30例,血压不波动的患儿为对照组30例,采用WX-10C微循环显微镜观察新生儿耳廓微循环,采血测定凝血酶原时间(PT),凝血酶时间(TT),部分活化凝血活酶时间(APTT),纤维蛋白原(Fib),对结果进行两组比较。【结果】血压增高组管袢形态、血流状态积分均高于对照组,差异有统计学意义(P<0.05);血压增高组的PT、APTT和TT下降,Fib增高,差异有统计学意义(P<0.05)。【结论】危重新生儿在血压增高时往往伴随着微循环和凝血功能障碍,在治疗原发病及降血压的同时需兼顾到微循环障碍和凝血功能障碍。
【Objective】 To observe the changes of microcirculation and coagulation function in critically ill children with high blood pressure, and provide the basis for treatment. 【Methods】 Thirty patients with elevated blood pressure in hospitalized critically ill newborn infants and 30 children with no fluctuating blood pressure were enrolled in this study. The microcirculation of the auricles of neonates was observed with WX-10C microcirculation microscope, Time (PT), thrombin time (TT), partial activated thromboplastin time (APTT), fibrinogen (Fib), the results were compared between the two groups. 【Results】 The results showed that the morphological and the blood flow state integrals were higher in hypertension group than those in control group (P <0.05). The levels of PT, APTT and TT were decreased and Fib was increased in hypertension group, the difference was statistically significant (P <0.05). 【Conclusions】 In critically ill newborns, microcirculation and coagulation dysfunction are often accompanied by increased blood pressure. In the treatment of primary disease and hypotension, both microcirculation disorders and coagulation disorders should be taken into account.