Objective:To investigate the effects of sevoflurane inhalation general anesthesia on serum IL-6,brain injury protein S100β and coagulation function in elderly patients undergoing total hip arthroplasty.Method: From May 2017 to May 2019, 84 patients,age 60-75 underwent total hip arthroplasty in our hospital.were randomly divided into two groups: group A (n=42) and group B (n=42).Group A was maintained with sevoflurane inhalation by general anesthesia and group B with propofol by intravenous anesthesia.The surgical related indexes and postoperative complications in the two groups were compared.The level of serum IL-6,S100β,Coagulation function index [platelet count (PLT), Fibrinogen (FIB), plasma D-dimer (D-D), activated partial enzyme activity time (APTT), prothrombin time (PT)],MMSE score and MoCA score were compared between two groups before and after operation.Results:There was no significant difference in anesthesia time, operation time, intraoperative bleeding and postoperative drainage (P >0.05).1h,1d and 7d after operation,the level of PLT,D-D and FIB in group A were significantly lower than that in group B (P<0.05),PT and APTT were significantly higher than that in group B (P<0.05).1h,1d and 7d after operation,the level of IL-6,S100βin group A were significantly lower than that in group B (P<0.05).1d after operation,the MMSE and MoCA scores in group B were significantly lower than those in group A (P<0.05).The incidence of lower extremity deep venous thrombosis (2.38％) and cognitive impairment (2.38％) in group A was lower than that in group B (14.29％, 16.67％)(t1=3.896,P1=0.048;t2=4.974,P2=0.026).Conclusion: sevoflurane anesthesia can reduce the incidence of deep venous thrombosis and cognitive impairment of the lower extremity after operation in elderly patients with thr, stabilize the coagulation index of patients, and downregulate the expression of il-6 and S100β.