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目的:了解某院严重药品不良反应(ADR)发生情况,为临床安全用药提供参考。方法:对某院2010年收集的52例严重ADR病例报告进行分类统计和分析评价。结果:本次统计中严重ADR的发生人群以女性居多,年龄段多集中在中老年,原患疾病主要是中枢神经系统疾病;所涉及的药品以中枢神经系统药物最多;给药途径以口服给药最多,其次为静脉滴注;以肝胆系统损害、中枢及外周神经系统损害、神经紊乱为主要的临床表现。结论:继续加强精神类药物的安全性监测,提高临床合理用药水平。
Objective: To understand the incidence of serious adverse drug reaction (ADR) in a hospital and provide references for clinical safety medication. Methods: 52 cases of severe ADR cases collected in a hospital in 2010 were classified and analyzed. Results: The incidence of severe ADR in this survey was mostly female, the age group mostly concentrated in the middle-aged and elderly. The original disease was mainly central nervous system disease. The drug involved in the central nervous system was the most. The route of administration was oral Followed by intravenous drip; the main clinical manifestations were liver and gallbladder system damage, central and peripheral nervous system damage and neurological disorders. Conclusion: Continue to strengthen the safety monitoring of psychotropic substances and improve the clinical rational use of drugs.