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目的 :探讨人胰岛素受体 (HINS R)基因多态性及低镁与DM患者高血压高发倾向的关系。方法 :采用PCR SSCP技术和ICP AES法分析了 6 3例 2型DMHINS RDNAEx 17多态性情况及RBCMg2 + 含量。结果 :Ex 17位点呈现多态性 5例 ,其RBCMg2 + 明显低于其它病例 (P <0 .0 1) ,而FINS水平明显高于对照组 (P <0 .0 1) ,其它DM伴高血压倾向者RBCMg2 + 也低于不伴高血压的DM者 ,血清Mg2 + 两组比较差异无显著性 (P >0 .0 5 )。结论 :HINS RDNAEx 17多态性常与高胰岛素血症或IR关联 ,且常伴细胞内Mg2 + 储备低下的情况 ,可被血清Mg2 + 正常的表面现象所掩盖 ,以上情况可强化DM伴高血压发病机制
Objective: To investigate the relationship between human insulin receptor (HINS R) gene polymorphism and the prevalence of hypertension in patients with DM. Methods: Sixty-three cases of type 2 DMHINS RDNAEx 17 polymorphism and RBCMg2 + content were analyzed by PCR SSCP and ICP-AES. Results: Ex 17 sites showed polymorphism in 5 cases, the RBCMg2 + was significantly lower than other cases (P <0.01), while FINS level was significantly higher than the control group (P <0.01), other DM with RBCMg2 + was also lower in those with high blood pressure than in those without DM, and there was no significant difference in serum Mg2 + between the two groups (P> 0.05). CONCLUSIONS: HINS RDNAEx 17 polymorphism is often associated with hyperinsulinemia or IR, and often accompanied by low levels of intracellular Mg2 + depletion, can be masked by the normal surface profile of serum Mg2 +, which may reinforce the association between DM with hypertension Pathogenesis