胎膜早破(PROM)是孕产期常见临床问题,可对胎儿和新生儿健康造成多方面的损害,尤其是导致其肺发育障碍和感染,甚至导致胎儿死亡或增加新生儿死亡率。本文结合本课题组在这方面的研究工作及国内外相关文献,对PROM及其对胎儿-新生儿的危害予以介绍,以加强其临床管理、改善PROM之胎儿-新生儿的预后。 Premature rupture of membranes (PROM) is a common clinical problem of pregnancy and childbirth, and can cause various damages to the fetus and newborn’s health, especially causing lung development disorders and infections, even causing fetal death or increasing neonatal mortality. In this paper, our research work in this area and relevant literature at home and abroad, on the PROM and its harm to the fetus - newborn to be introduced to strengthen its clinical management and improve the prognosis of PROM fetus - newborn.