论文部分内容阅读
目的:联合检测CEA、NSE、CYFRA21-1、SCCAg、TPS等5种血清肿瘤标志物水平,以寻找具有组织学特异性的肺癌肿瘤标志物,指导肺癌诊断、肺癌病理学分析,选择合理的治疗方案。方法:应用免疫放射法及酶联免疫法分别检测试验组(108例肺癌患者)、对照组(34例肺良性病患者)及健康组(50例健康体检者)血清中CEA、NSE、CYFRA21-1、SCCAg、TPS等5种血清肿瘤标志物水平,并采用t检验对数据结果进行统计学分析。结果:实验组血清中的5项肿瘤标志物含量均高于其他两组;肿瘤标志物水平还与病理类型有关,CEA水平在肺腺癌中最高,NSE在肺小细胞癌中最高,CYFRA21-1、SCCAg、TPS在肺鳞癌中最高;血清肿瘤标志物联合检测上述3种肺癌的阳性率显著升高,分别达到79%、89.8%、88.4%。结论:5种肿瘤标志物对肺癌的诊断有临床价值,并便于确定病理类型,且联合检测可以提高肺癌诊断的敏感性,大大提高肺癌的检出率。
OBJECTIVE: To detect the levels of 5 serum tumor markers, including CEA, NSE, CYFRA21-1, SCCAg and TPS, in order to find histological specific lung cancer tumor markers, to guide the diagnosis of lung cancer and pathological analysis of lung cancer, and to select appropriate treatment Program. Methods: Serum levels of CEA, NSE, CYFRA21-C and TNF-α in sera of 108 patients with lung cancer, 34 patients with benign lung disease and 50 healthy controls were detected by immunoassay and enzyme-linked immunosorbent assay 1, SCCAg, TPS and other five kinds of serum tumor markers, and using t test data for statistical analysis. Results: The levels of 5 tumor markers in the serum of the experimental group were higher than those of the other two groups. The level of the tumor marker was also related to the pathological type. The CEA level was highest in lung adenocarcinoma, NSE was the highest in small cell lung cancer, CYFRA21- 1, SCCAg and TPS were the highest in squamous cell carcinoma of the lung. The positive rates of serum tumor markers in combination with the above three kinds of lung cancer were significantly higher (79%, 89.8% and 88.4% respectively). CONCLUSION: The five tumor markers have clinical value for the diagnosis of lung cancer and are easy to determine the pathological type. Combined detection can improve the sensitivity of lung cancer diagnosis and greatly improve the detection rate of lung cancer.