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目的探讨重症肺炎患儿血清可溶性细胞间黏附分子-1(sICAM-1)水平的变化,以及不同病原体所致重症肺炎血清sICAM-1的水平及其临床意义。方法采用双抗体夹心酶联免疫吸附法测定40例重症肺炎患儿和43例普通肺炎患儿急性期、恢复期、以及48例健康对照组小儿血清sICAM-1水平。结果重症肺炎急性期血清sICAM-1水平明显高于重症肺炎恢复期,差异有非常显著性(P<0.01);与普通肺炎急性期与健康对照组比较,差异有非常显著性(P<0.01);重症肺炎恢复期血清sICAM-1水平与普通肺炎恢复期及健康对照组比较,则差异均无显著性(P>0.05);重症细菌性肺炎、病毒性肺炎、支原体肺炎、病毒与细菌混合感染性肺炎急性期血清sICAM-1水平比较,差异均无显著性(P>0.05)。结论重症肺炎患儿急性期血清sICAM-1水平较普通肺炎急性期明显增高,但不同病原体所致重症肺炎血清sICAM-1水平变化无统计学意义;sICAM-1参与了重症肺炎的炎症过程,其水平的高低可以作为肺炎病情轻重的判断指标之一。
Objective To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1) in children with severe pneumonia and the level of serum sICAM-1 in patients with severe pneumonia and its clinical significance. Methods Serum levels of sICAM-1 in 40 children with severe pneumonia and 43 children with common pneumonia were measured by double antibody sandwich enzyme-linked immunosorbent assay in acute and convalescent periods and in 48 healthy controls. Results Serum levels of sICAM-1 in patients with acute severe pneumonia were significantly higher than those in patients with severe pneumonia (P <0.01). Compared with healthy controls, the levels of serum sICAM-1 in patients with severe pneumonia were significantly different (P <0.01) ; The level of serum sICAM-1 in convalescent pneumonia was not significantly different from that in healthy convalescent group (P> 0.05); Severe bacterial pneumonia, viral pneumonia, mycoplasma pneumonia, mixed virus and bacterial infection Serum levels of sICAM-1 in patients with acute pneumonia were not significantly different (P> 0.05). Conclusions Serum level of sICAM-1 in children with severe pneumonia is significantly higher than that in common acute pneumonia, but serum sICAM-1 levels in severe pneumonia are not significantly different among different pathogens. SICAM-1 is involved in the inflammatory process of severe pneumonia. Level of the severity of pneumonia can be used as one of the indicators to determine the severity.