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帕金森症的果蝇模型对解析疾病的分子细胞机制贡献极大.为探讨利用地中海黑腹果蝇的疾病模型来筛选新型治疗帕金森症药物的可能性,我们构建了基于DJ-1A和PINK1两个遗传致病因子的帕金森症果蝇模型,测试抗氧化和消炎活性分子米诺环素和辅酶Q10对脑多巴胺浓度的影响.结果表明,米诺环素对DJ-1A果蝇模型有明显保护作用,能显著提高脑多巴胺的浓度,但是对PINK1果蝇模型没有保护作用;辅酶Q10对两种模型均有保护作用.因此,帕金森病的果蝇模型能够反映药物分子的特异性作用,为筛选新的帕金森病治疗药物提供了一条便捷的途径.
The Drosophila model of Parkinson’s disease contributes significantly to the molecular cellular mechanisms of disease resolution.To explore the possibility of using a disease model of Drosophila melanogaster to screen novel drug candidates for Parkinson’s disease we constructed a model based on DJ-1A and PINK1 Two genetic risk factors of Parkinson’s disease in the Drosophila model to test anti-oxidation and anti-inflammatory activity of molecules minocycline and coenzyme Q10 on brain dopamine concentration.The results showed that minocycline DJ-1A fruit fly model Significant protective effect, can significantly increase brain dopamine concentration, but no protective effect on the PINK1 flies model; coenzyme Q10 have protective effect on both models, therefore, the Parkinson’s disease flies model can reflect the specific role of drug molecules , Providing a convenient way to screen new drugs for treating Parkinson’s disease.