仅依临床表现是难于把目光性角化病与鳞状细胞癌、基底细胞癌、角化棘皮瘤,或皮脂性角化病区分开。基于此因,就需取一或多块有代表性或可疑病变组织作病理组织学检查。为此,所取的活检标本就应包括表皮和真皮。如活检标本太小或太浅都将会漏掉某些重要的组织学改变,如异型增生或真皮内浸润。 According to clinical manifestations, it is difficult to distinguish between visual keratoderma and squamous cell carcinoma, basal cell carcinoma, keratoacanthoma, or sebaceous keratosis. For this reason, one or more representative or suspicious lesions should be taken for histopathological examination. For this purpose, the biopsy specimens taken should include the epidermis and dermis. If the biopsy specimen is too small or too shallow, it will miss some important histological changes, such as dysplasia or intradermal infiltration.